Abstract
Benzo[b]furan and indole analogues of some recently identified benzo[b]thiophene inhibitors of tubulin polymerization have been prepared, and their biological activity has been assessed. Several very potent analogues were identified.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Benzofurans / chemical synthesis*
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Benzofurans / chemistry
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Benzofurans / pharmacology
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Biopolymers
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Cell Division / drug effects
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Colchicine / chemistry
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Drug Screening Assays, Antitumor
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Humans
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Indoles / chemical synthesis*
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Indoles / chemistry
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Indoles / pharmacology
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Protein Binding
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Structure-Activity Relationship
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Tubulin / chemistry*
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Benzofurans
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Biopolymers
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Indoles
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Tubulin
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Colchicine